Macromolecular ketoaldehydes
AssigneesBaxter International Inc., Baxter Healthcare S.A.
InventorsMitchell J. Poss, Henk Blom, Alex Odufu, Robert Smakman
Life of this patent
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Abstract
Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.
Claims28
A method of producing a macromolecular composition capable of removing an effective amount of one or more constituents from a solution, the method comprising the steps of:
- preparing a resin material that includes a phenyl group;
- forming an acetyl group on the phenyl group;
- and
- oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group.
A method of preparing a macromolecular composition including an aromatic alpha-ketoaldehyde, the method comprising the steps of:
- preparing a polymeric material including a phenyl group;
- acetylating the polymeric material thereby attaching an acetyl group to the phenyl group;
- and
- oxidizing the acetyl group via a one-step reaction including reacting the acetyl group with a sulfoxide and a hydrohalic acid thereby forming an alpha-ketoaldehyde.
A method of producing a binder material, the method comprising the steps of:
- preparing a resin material;
- forming an acetyl group;
- and
- oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and a hydrohalic acid with the acetyl group to form a glyoxal group wherein the binder material is capable of capable of removing an effective amount of one or more constituents from a physiological solution.
A macromolecular composition capable of removing an effective amount of one or more constituents from a solution, the macromolecular composition comprising an alpha-ketoaldehyde group attached to a phenyl group formed by oxidation of an acetylated macromolecular composition via a single-step reaction that includes reacting the acetylated macromolecular composition with a sulfoxide and a hydrohalic acid thereby forming the alpha-ketoaldehyde group.
A method of providing dialysis therapy, the method comprising the steps of:
- passing a physiological fluid through a device wherein at least a portion of the device at least includes a macromolecular composition, the macromolecular composition comprising an alpha-ketoaldehyde group attached to a phenyl group formed by oxidation of an acetylated macromolecular composition via a single-step reaction that includes reacting the acetylated macromolecular composition with a sulfoxide and a hydrohalic acid thereby forming the ketoaldehyde group;
- and
- removing one or more constituents from the physiological fluid.
Dependencies are inferred from the claim text.