Polycarbonate-polyurethane dispersions for thrombo-resistant coatings

A process for rendering a medical device bio-compatible comprising:

• a) providing a substrate with a coating comprising an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition having at least one internal emulsifying agent;
• and
• b) drying said coating onto said substrate to attach said coating to said substrate.

A coating for enhancing the bio-activity of a surface of a medical device, said coating formed from an aqueous emulsion or dispersion comprising a polycarbonate-polyurethane composition containing an organic acid functional group and an excess of a polyfunctional cross-linking agent, said composition forming a coating on a surface of said medical device and being bonded thereto and reactive with bio-active agents.

A medical device with enhanced thrombo-resistance comprising:

• a) a substrate having a surface to which a continuous thrombo-resistant coating may be attached;
• and
• b) a thrombo-resistant coating that contains an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition containing an internal emulsifying agent, said composition being attached to said substrate surface.

A medical device having a surface rendered bio-compatible by means of a first coating layer, said first coating layer comprising a polycarbonate-polyurethane composition containing an internal emulsifying agent.

A medical device having a surface coated with a bio-active layer comprising the reaction product of a polycarbonate-polyurethane first layer containing an internal emulsifying agent and a polyfunctional cross-linking agent and a bio-active agent second layer having at least one organic acid functional group.