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OwnerKatrien Maria Jozefa Van Laere, Rene John Raggersinventors
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Method of inhibiting intestinal carbohydrate absorption in mammals and a dietetic preparation for use in such a method. The method comprises orally administering a dietetic preparation to such mammal, the preparation containing a-hydroxy carboxylic acid component, whose intestinal absorption is sodium dependent, in an amount equivalent to at least 1 wt. % citric acid, so as to provide a-hydroxy carboxylic acid component in an amount which is therapeutically effective to achieve inhibition of intestinal absorption of carbohydrate. The dietetic preparation is in the form of an oral dosage unit of between 0.1 and 100 grams, and contains between 2 and 90 wt. % of a-hydroxy carboxylic acid component, between 1 and 80 wt. % of a carbohydrate absorption inhibitor and between 97 and 9 wt. % of pharmaceutically acceptable excipient.
Use of citric acid component in the manufacture of a dietetic preparation for use in a method for inhibiting intestinal absorption of carbohydrates in a mammal, which method comprises orally administering the dietetic preparation to such mammal, said preparation containing citric acid component selected from the group consisting of citric acid, citric acid salts, citric acid estes and mixtures thereof in an amount equivalent to at least 1 wt. % citric acid, so as to provide citric acid component in an amount which is therapeutically effective to achieve inhibition of intestinal absorption of carbohydrate.
Use according to any one of the preceding claims, wherein the preparation is administered no more than 60 minutes before or after consumption of a foodstuff containing at least 20 g of digestible carbohydrates.
Use according to any one of the preceding claims, wherein the preparation comprises less than 60 wt. % digestible carbohydrates based on dry weight of the preparation.
Use according to any one of the preceding claims, wherein the method comprises administration of the preparation in dosage units of between 0.1 and 100 g.
Use according to any one of the preceding claims, wherein the preparation contains citric acid component in an amount equivalent to between 50 and 3000 mg citric acid.
Use according to any one of the preceding claims, wherein the preparation additionally contains an intestinal carbohydrase inhibitor selected from the group consisting of Phaseolus vulgaris (phaseolamin), roselle tea, lotus, arabinose, inosine, adenosine, evening primrose extract, banaba extract, Epimedium extract, indigestible dextrin, polyphenols and mixtures thereof.
Use according to any one of the preceding claims, wherein the preparation additionally contains a monosaccharide uptake inhibitor selected from the group consisting of pectin, guar gum, Konjak mannan, locust bean gum, oat fibre, inulin and mixtures thereof.
Dietetic preparation in the form of an oral dosage unit of between 0.1 and 100 grams, said preparation containing between 2 and 90 wt. % citric acid component between 1 and 80 wt. % of a carbohydrate absorption inhibitor selected from the group consisting of polyphenols, gymnemic acid, Epimedium plant material and mixtures thereof and between 97 and 9 wt. % of pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.