Use of protein essential aminoacids to treat amenorrhea and related disorders
OwnerPatrick Ammann, Rene Rizolli +1inventors
InventorsPatrick Ammann, Rene Rizolli, Jean-Philippe Bonjour
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Abstract
Malnourishment leading to a decrease in body weight interferes with estrogen secretion in women, causing deleterious effects on bone density and on the menstrual cycle. The invention is based on the discovery that it is possible to reverse these metabolic effects of malnourishment by boosting protein intake, as whole protein or as a blend of essential amino acids. The proteins may be administered in the form of a dietary supplement, as a foodstuff, or as a component of a complete meal.
Claims27
Use of two or more essential amino acids in free form or in salt form in the manufacture of a medicament or nutritional formulation for the restoration of normal physiological levels of estrogen in a premenopausal woman suffering from malnourishment.
Use of two or more essential amino acids in free form or in salt form in the manufacture of a medicament or nutritional formulation for the prevention or treatment of amenorrhea, oligomenorrhea or erratic menstruation, especially that caused by malnourishment.
Use of two or more essential amino acids in free form or in salt form in the manufacture of a medicament or nutritional formulation for the prevention or treatment of osteopenia or osteoporosis in a premenopausal woman suffering from amenorrhea, oligomenorrhea or erratic menstruation.
Use of two or more essential amino acids in free form or in salt form in the manufacture of a medicament or nutritional formulation for the prevention or reversal of body weight loss and/or loss of muscle mass in a premenopausal woman suffering from amenorrhea, oligomenorrhea or erratic menstruation due to malnourishment.
Use of protein in the manufacture of a nutritional formulation for the prevention or treatment of amenorrhea, oligomenorrhea or erratic menstruation in a premenopausal woman suffering from malnourishment, wherein said nutritional formulation comprises at least 20 en % protein and is in the form of a carbonated or non-carbonated soft drink, a juice, a sports drink, a milk drink, a milk-shake, a yoghurt drink, a smoothie, a soy-based drink, a soup, a cereal bar, a dairy bar, a snack-food, a breakfast cereal, a candy, a tab, a cookie, a cracker, chocolate, chewing-gum, or a dessert.
Use of protein in the manufacture of a complete formula diet or enteral feeding solution for the prevention or treatment of osteopenia or osteoporosis due to malnourishment in a premenopausal woman suffering from amenorrhea, oligomenorrhea or erratic menstruation, wherein said complete formula diet or enteral feeding solution comprises at least 20 en % protein.
Use of protein in the manufacture of a complete formula diet or enteral feeding solution for the prevention or treatment of amenorrhea, oligomenorrhea or erratic menstruation in a premenopausal woman, especially a woman suffering from malnourishment, wherein said complete formula diet or enteral feeding solution comprises at least 20 en % protein.
A pharmaceutical or nutritional composition for preventing or treating osteopenia, osteoporosis, amenorrhea, oligomenorrhea or erratic menstruation comprising a blend of amino acids in free form or in salt form, wherein said amino acid blend consists of leucine, lysine, isoleucine, phenylalanine, valine, arginine, threonine, histidine and tryptophan.
A method of treatment to restore normal physiological levels of estrogen in a pre-menopausal woman suffering from malnourishment and in need of such treatment, comprising altering the diet of said woman by increasing the proportion of protein relative to the sum of carbohydrate and fat, as a percentage of total calories, in the diet, or administering a nutritional formulation or medicament comprising protein in an amount such that the total protein content of the diet is at least 20 en %, or at least 25 en %, preferably at least 30 en %.
A method for preventing or treating amenorrhea, oligomenorrhea or erratic menstruation in a pre-menopausal woman, particularly a woman suffering from malnourishment, comprising altering the diet of said woman by increasing the proportion of protein relative to the sum of carbohydrate and fat, as a percentage of total calories, in the diet, or administering a nutritional formulation or medicament comprising protein in an amount such that the total protein content of the diet is at least 20 en %, or at least 25 en %, preferably at least 30 en %.
A method of preventing or treating osteopenia or osteoporosis, in a pre-menopausal woman suffering from amenorrhea, oligomenorrhea or erratic menstruation, especially that due to malnourishment, comprising altering the diet of said woman by increasing the proportion of protein relative to the sum of carbohydrate and fat, as a percentage of total calories, in the diet, or administering a nutritional formulation or medicament comprising protein in an amount such that the total protein content of the diet is at least 20 en %, or at least 25 en %, preferably at least 30 en %.
A method of preventing or reversing body weight loss and/or loss of muscle mass in a pre-menopausal woman suffering from amenorrhea, oligomenorrhea or erratic menstruation due to malnourishment, comprising altering the diet of said woman by increasing the proportion of protein relative to the sum of carbohydrate and fat, as a percentage of total calories, in the diet, or administering a nutritional formulation or medicament comprising protein in an amount such that the total protein content of the diet is at least 20 en %, or at least 25 en %, preferably at least 30 en %.
A method according to any preceding claim wherein the proportion of protein in said diet is increased to at least 25 en %, optionally at least 30 en %.
Dependencies are inferred from the claim text.