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US 2004/0171670 A1Published application
Compounds active at a novel site on receptor-operated calcium channels useful for treatment of neurological disorders and diseases
AssigneeNPS Pharmaceuticals, Inc.
InventorsAlan L. Mueller, Scott T. Moe
Life of this patent
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Abstract
Method and compositions for treating a patient having a neurological disease or disorder, such as stroke, head trauma, spinal cord injury, spinal cord ischemia, ischemia- or hypoxia-induced nerve cell damage, epilepsy, anxiety, neuropsychiatric or cognitive deficits due to ischemia or hypoxia such as those that frequently occur as a consequence of cardiac surgery under cardiopulmonary bypass, or neurodegenerative diseases such as Alzheimer's Disease, Huntington's Disease, Parkinson's Disease, or amyotrophic lateral sclerosis (ALS).
Claims1
A compound of Formula VIII:
- 360
- wherein:
- Z is selected from the group consisting of —CH2CH2—, —CH2CH(CH3)—, —CH═CH—, —O—CH2—, —S—CH2—, —O—, and —S—;
- X1 and X2 are independently selected from the group consisting of —F, —Cl, —CH3, —OH, and lower O-alkyl in the 1-, 3-, 7-, or 9-substituent positions;
- m is independently an integer from 0 to 2;
- —NHR is selected from the group consisting of —NH2, —NHCH3, and —NHC2H5;
- R1 is selected from the group consisting of —H, alkyl, hydroxyalkyl, —OH, —O-alkyl, and —O-acyl, and
- R2 is selected from the group consisting of —H, alkyl, hydroxyalkyl, and pharmaceutically acceptable salts and complexes thereof, wherein the compound is active at an NMDA receptor.
5 more elements
Dependencies are inferred from the claim text.