Therapeutic compositions for intranasal administration which include KETOROLAC
AssigneeRecordati S.A., Chemical and Pharmaceutical Company, A corporation of Switzerland
InventorsGiancarlo Santus, Giuseppe Bottoni, Ettore Bilato
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Abstract
An analgesic/anti-inflammatory pharmaceutical dosage form which comprises an effective amount of an active ingredient selected from the group consisting of racemic 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, optically active forms thereof and pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable excipient or diluent, said dosage form being an intranasally administrable dosage form.
Claims29
An analgesic pharmaceutical aqueous dosage form suitable for treating pain by providing a systemic effect through intranasal administration by spraying into a nasal cavity, which dosage form comprises an effective amount of an active ingredient selected from the group consisting of racemic 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, of the formula
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- optically active forms therefor and pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable excipient or diluent.
A method for the treatment of pain in a patient in need thereof, which method comprises spraying into a nasal cavity of the patient an aqueous composition comprising an effective amount of the active ingredient 5-benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid, in a racemic or optically active form or in the form of a pharmaceutically acceptable salt.
An article of manufacture comprising an atomizer containing an aqueous analgesic pharmaceutical composition that comprises an effective amount of an active ingredient selected from the group consisting of racemic 5-benzoyl-2,3-dihyrdo-1H-pyrrolizine-1-carboxylic acid of the formula
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- optically active forms therefor and pharmaceutically acceptable salts thereof, in combination with a pharmaceutically acceptable excipient or diluent, said composition being intranasally administrable for the treatment of pain.
Dependencies are inferred from the claim text.