Single dose aromatase inhibitor for treating infertility
AssigneeAres Trading S.A.
InventorsRobert F. Casper, Mohamed F. M. Mitwally
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AssigneeAres Trading S.A.
InventorsRobert F. Casper, Mohamed F. M. Mitwally
Estimating the term…
The use of an aromatase inhibitor (AI) in the preparation of a medicament for use in inducing ovulation in a female suffering from anovulatory infertility which comprises administering to said female a single dose of the at least one aromatase inhibitor. The use of an aromatase inhibitor (AI) for the preparation of a medicament comprising a single dose of at least one aromatase inhibitor (AI) for administration to an ovulating female suffering from unexplained infertility or other types of ovulatory infertility early in one or more menstrual cycles. Such a medicament may also be administered to an anovulatory female in combination with a plurality of daily doses of follicle stimulating hormone (FSH) whereby the dosage levels of FSH may be reduced. The use of AI in the preparation of a medicament for administration to a female who is a poor responder to FSH, which comprises a combination of a single dose of AI with a plurality of daily doses of FSH is also disclosed. The related pharmaceutical preparations and packages are also described.
Use of an aromatase inhibitor for the preparation of a medicament for inducing ovulation in a female suffering from anovulatory infertility, wherein the medicament is administered as a single dose of at least one aromatase inhibitor.
Use as claimed in any one preceding claim, wherein the aromatase inhibitor is selected from non-steroidal and reversible aromatase inhibitors.
Use as claimed in any one preceding claim, wherein the aromatase inhibitor is administered orally.
Use as claimed in any one preceding claim, wherein the amount of aromatase inhibitor is selected from amounts that lower estrogen levels to post-menopausal levels in a female.
Use as claimed in any one preceding claim, wherein the amount of aromatase inhibitor is selected from amounts that lower estrogen levels to at or about 100 pmol/L or less as measured by standard immunoassay techniques.
Use as claimed in any one preceding claims, wherein the aromatase inhibitor is administered in a single dose selected from amounts in the range of from at or about 5 mg to at or about 500 mg.
Use as claimed in any one preceding claim, wherein the aromatase inhibitor is administered in a single dose selected from amounts comprising 5 mg, 10 mg, 20 mg, 25 mg or 30 mg.
Use as claimed in any one preceding claim, wherein the medicament is administered on any one of days 1 to 5 of the menstrual cycle.
Use according to any one preceding claim, wherein the medicament is administered on day 3 of the menstrual cycle.
Use of an aromatase inhibitor for the preparation of a medicament for augmenting ovulation in an ovulating female suffering from unexplained infertility or other types of ovulatory infertility, wherein the medicament is administered to said female as a single dose of at least one aromatase Inhibitor (AI) early in one or more menstrual cycles.
Use of an aromatase inhibitor for the preparation of a medicament for use with follicle stimulating hormone (FSH) in the treatment of an anovulatory female for infertility, wherein the medicament is administered as single dose.
Use of a single dose of an aromatase inhibitor (AI) for the preparation of a medicament for use with follicle stimulating hormone (FSH) in the treatment of a female for infertility, wherein the female is considered to be a poor responder to FSH, wherein the medication is administered as a single dose.
Use as claimed in any one preceding claim, wherein the aromatase inhibitor is administered on any one of days 1 to 5 of the menstrual cycle.
Use as claimed in any one preceding claim, wherein the aromatase inhibitor is administered on day 3 of the menstrual cycle.
A kit for treating infertility in a female comprising a single dose of an aromatase inhibitor together with a pharmaceutically acceptable carrier in combination with a plurality of daily doses of follicle stimulating hormone together with a pharmaceutically acceptable carrier.
A pharmaceutical package, comprising a single dose of an aromatase inhibitor, and instructions for its use in ovulation induction.
A pharmaceutical package, comprising a single dose of an aromatase inhibitor, a plurality of doses of FSH, and instructions for its use in ovulation induction in a female patient.
Dependencies are inferred from the claim text.