Dual-function microbicides
AssigneeParker Hughes Institute
InventorsFatih M. Uckun, Osmond D'Cruz
Life of this patent
Estimating the term…
Abstract
Contraceptive activity as well as anti-microbial, particularly anti-viral protection is provided by contraceptive compositions containing a thiourea compound of the invention exhibiting spermicidal or sperm-immobilizing activity. Preferred compounds of the invention are cyclohexenyl-substituted thiourea compounds.
Claims12
A method of inhibiting conception in a mammal, comprising contacting mammalian sperm with an effective spermicidal or sperm-immobilizing amount of a thiourea compound having the formula:
- 14
- where R1 is cyclohexenyl, and R2 is halo or CF3.
A contraceptive composition, comprising an amount effective for inhibiting conception of thiourea compound having the formula:
- 15
- where R1 is cyclohexenyl, and R2 is halo or CF3;
- and a carrier, diluent or vehicle suitable for contraceptive use.
A method of inhibiting conception in a mammal, comprising contacting mammalian sperm with an effective spermicidal or sperm-immobilizing amount of a thiourea compound having the formula:
- 16
- where R1 is pyridyl and R2 is H.
A method of inhibiting conception in a mammal, comprising contacting mammalian sperm with an effective spermicidal or sperm-immobilizing amount of a thiourea compound having the formula:
- 17
- where R1 is piperidinyl and R2 is CF3.
Dependencies are inferred from the claim text.