S(-)rabeprazole compositions and methods
AssigneeSepracor Inc.
InventorsPatrick Koch, Paul D. Rubin, William E. Yelle
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Abstract
Methods and compositions are disclosed utilizing optically pure S(−)rabeprazole for the treatment of ulcers in humans while substantially reducing the concomitant liability of adverse effects associated with the racemic mixture of rabeprazole. The optically pure S(−) isomer is also useful for the treatment of gastroesophageal reflux. S(−)rabeprazole is an inhibitor of H+ release and is therefore useful in the treatment of other conditions related to gastric hypersecretion such as Zollinger-Ellison Syndrome.
Claims20
A method of treating ulcers in a human which comprises administering to a human in need of treatment for ulcers, a therapeutically effective amount of rabeprazole, the rabeprazole comprising optically pure S(−)rabeprazole, or a pharmaceutically acceptable salt thereof.
A method of treating gastroesophageal reflux disease in a human which comprises administering to a human in need of treatment for gastroesophageal reflux disease, a therapeutically effective amount of rabeprazole, the rabeprazole comprising optically pure S(−)rabeprazole, or a pharmaceutically acceptable salt thereof.
A method of treating a condition caused by or contributed to by gastric hypersecretion in a human which comprises administering to a human in need of treatment for a condition caused by or contributed to by gastric hypersecretion, a therapeutically effective amount of rabeprazole, the rabeprazole comprising optically pure S(−)rabeprazole, or a pharmaceutically acceptable salt thereof.
A method of treating psoriasis in a human which comprises administering to a human in need of treatment for psoriasis, a therapeutically effective amount of rabeprazole, the rabeprazole comprising optically pure S(−)rabeprazole, or a pharmaceutically acceptable salt thereof.
A pharmaceutical composition comprising a therapeutically effective amount of rabeprazole, containing at least approximately 90% by weight S(−)rabeprazole and 10% or less by weight R(+)rabeprazole, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier for oral administration of the composition.
Dependencies are inferred from the claim text.