Acylaminothiazole derivatives, their preparation and therapeutic use

A compound corresponding to the general formula (I):

• 85
• in which,
• n is equal to 0, 1, 2 or 3;
• X represents an oxygen or sulfur atom;
• R1 represents, independently of each other when n=2 or 3, a halogen atom, a hydroxyl, a C1-3 alkyl, a C1-3 alkoxy, a trifluoromethyl, a trifluoromethyloxy or a methylenedioxy;
• R2 represents a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group, a phenyl, a C1-3 alkoxy group, a hydroxyl or a halogen atom;
• a C3-7 cycloalkyl, piperidinyl or phenyl group;
• the C3-7 cycloalkyl, piperidinyl and phenyl groups being optionally substituted with one or more C1-3 alkyl groups, C1-3 alkoxy groups, a hydroxyl or a halogen atom;
• R3 represents a hydrogen atom or a C1-6 alkyl group optionally substituted with a C3-7 cycloalkyl group;
• R4 represents a hydrogen atom or a C1-4 alkyl group;
• R5 and R5′ represent, independently of each other, a hydrogen atom, a hydroxyl, a halogen atom, a C1-3 alkyl group;
• or R5 and R5′ form together an oxo group;
• and
• R6 represents a hydrogen atom, a halogen atom, a C1-3 alkyl, a C1-3 alkoxy, a trifluoromethyl or a trifluoromethoxy;
• in the form of a base, of an addition salt with an acid, of a hydrate or of a solvate.