Compositions and methods for targeting cerebral circulation and treatment of headache
OwnerBruce Fromeinventor
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Abstract
Methods and compositions for targeting cerebral circulation and treatment of headache include formulations comprising a pharmacologically active substance in a transdermal formulation, which is topically applied to an area of skin superficial to a carotid artery, a temporal artery, a vertebral artery, or to a tender spot associated with a headache. Particularly preferred formulations include a xanthine derivative (e.g., theophylline, caffeine, aminophylline), and may further comprise ketoprofen. Contemplated methods further include methods of advertising use of contemplated compositions.
Claims46
A method of directing a pharmacologically active substance to a cerebral circulation, comprising:
- providing a composition that includes a pharmacologically active substance;
- including the composition in a transdermal formulation;
- and
- topically applying the transdermal formulation to at least one area of skin superficial to a carotid artery, a temporal artery, and a vertebral artery, wherein the transdermal formulation is applied in an amount effective to deliver the pharmacologically active substance to the cerebral circulation.
A method of treating a person having a headache, comprising:
- providing a composition that includes a pharmacologically active substance;
- identifying at least one tender spot associated with the headache on a body surface of the person;
- and
- topically applying the composition to the tender spot in an amount effective to reduce the headache.
A composition comprising:
- at least one xanthine derivative and ketoprofen.
A method of marketing a product, comprising:
- including a skin penetration enhancer and a pharmacologically active substance as a component of the product;
- instructing a person to identify at least one tender spot associated with a headache on a body surface of the person;
- and
- instructing the person to topically apply the product to the tender spot in an amount effective to reduce the headache.
A method of marketing a product, comprising:
- including a skin penetration enhancer and a pharmacological active substance as a component of the product;
- instructing a person to identify at least one area of skin superficial to at least one of a carotid artery, a temporal artery, and a vertebral artery;
- and
- instructing the person to topically apply the product to the area in an amount effective to direct the pharmacological active substance to a cerebral circulation of the person.
A method of prophylactic treatment of a patient to avoid a headache, comprising:
- providing a composition that includes a pharmacologically active substance;
- including the composition in a transdermal formulation;
- and
- topically applying the transdermal formulation to at least one area of skin superficial to a carotid artery, a temporal artery, and a vertebral artery, wherein the transdermal formulation is applied in an amount effective to prevent onset of the headache.
A method of prophylactic treatment of a patient to avoid a headache, comprising:
- providing a composition that includes a pharmacologically active substance;
- identifying at least one tender spot associated with onset of the headache on a body surface of the person;
- and
- topically applying the composition to the tender spot in an amount effective to reduce the headache.
A method of treatment of a patient having an ischemic stroke, comprising:
- providing a composition having at least one of a vasodilatory agent and an anticoagulant;
- including the composition in a transdermal formulation;
- topically applying the transdermal formulation to at least one area of skin superficial to a carotid artery, a temporal artery, and a vertebral artery;
- and
- wherein the transdermal formulation is applied in an amount effective to deliver the at least one of the vasodilatory agent and anticoagulant to a cerebral circulation of the patient, thereby improving blood flow in an area affected by reduction of blood flow.
The method of claim 43 wherein the vasodilatory agent is niacin and present in the transdermal formulation at a concentration of 5% (by weight).
A method of reducing fever in a patient, comprising:
- providing a composition that includes a fever reducing agent;
- including the composition in a transdermal formulation;
- topically applying the transdermal formulation to at least one area of skin superficial to a carotid artery, a temporal artery, and a vertebral artery;
- and
- wherein the transdermal formulation is applied in an amount effective to deliver the fever reducing agent to a cerebral circulation, thereby reducing an elevated body temperature of the patient.
Dependencies are inferred from the claim text.