Chemical compounds

A compound of formula (1)

• 30
• wherein:
• R1 and R2 each independently represent a C1-6alkyl, C3-6alkenyl, C3-6cycloalkylC1-3alkyl or C3-6cycloalkyl;
• each of which may be optionally substituted by 1 to 3 halogen atoms;
• R3 is a group —CON(R10)YR11 or —SO2N(R10)YR11;
• [wherein Y is O, S or NR12 (wherein R12 is hydrogen or C1-6alkyl);
• and R10 and R11 are independently C1-6alkyl optionally substituted by halo, hydroxy, amino, C1-6alkylamino or di-(C1-6alkyl)amino];
• Q is —CO— or —C(R4)(R5)— (wherein R4 is a hydrogen atom or C1-4alkyl and R5 is a hydrogen atom or hydroxy group);
• Ar is a 5- to 10-membered aromatic ring system wherein up to 4 ring atoms may be heteroatoms independently selected from nitrogen, oxygen and sulphur, the ring system being optionally substituted by one or more substituents independently selected from C1-4alkyl (optionally substituted by 1, 2 or 3 hydroxy groups), C1-4alkoxy, halogen, haloalkyl, dihaloalkyl, trihaloalkyl, C1-4alkoxyC1-4alkyl, C1-4alkylthio, C1-4alkoxycarbonyl, C2-4alkanoyl, oxo, thioxo, nitro, cyano, —N(R6)R7 and —CH2)pN(R8)R9, hydroxy, C1-4alkylsulphonyl, C1-4alkylsulphinyl, carbamoyl, C1-4alkylcarbamoyl, di-(C1-4alkyl)carbamoyl, carboxy, or a 5 or 6 membered aromatic ring containing up to 4 heteroatoms independently selected from nitrogen, oxygen and sulphur;
• p is 1 to 4
• R6 and R7 each independently represent a hydrogen atom, C1-4alkanoyl or C1-4alkyl, or together with the nitrogen atom to which they are attached form a 5- to 7-membered saturated heterocyclic ring;
• R8 and R9 each independently represent a hydrogen atom, C1-4alkanoyl or C1-4alkyl, or together with the nitrogen atom to which they are attached form a 5- to 7-membered saturated heterocyclic ring;
• or a pharmaceutically acceptable salt or prodrug thereof.