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AssigneeAlexza Molecular Delivery Corporation
InventorsJoshua D. Rabinowitz, Alejandro C. Zaffaroni
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The present invention relates to the delivery of compounds for the treatment of anxiety disorders and symptoms of such disorders through an inhalation route. Specifically, it relates to aerosols containing that are used in inhalation therapy. In a method aspect of the present invention, diazepam is administered to a patient through an inhalation route. The method comprises: a) heating a composition, comprising diazepam to form a vapor; and, b) allowing the vapor to cool, thereby forming a condensation aerosol with less than 5% of the drug degradation products. In a kit aspect of the present invention, a kit for delivering diazepam through an inhalation route is provided which comprises: a) a thin coating of a diazepam composition; and, b) a device for dispending said thin coating as a condensation aerosol
A method of treating anxiety disorders or symptoms comprising administering a therapeutic amount of a diazepam condensation aerosol, having an MMAD less than 3 μm and less than 5% diazepam degradation products, to a patient by inhalation, upon activation by the patient of the formation of, and delivery of, the condensation aerosol.
A method of administering diazepam to a patient to achieve a peak plasma drug concentration rapidly, comprising administering to the patient by inhalation an aerosol of diazepam having less than 5% diazepam products and an MMAD less than 3 microns wherein the peak plasma drug concentration is achieved in less than 0.1 hours.
A kit for delivering a drug aerosol comprising:
Dependencies are inferred from the claim text.