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US 2004/0171597 A1Published application
Anti-inflammatory 17.beta.-carbothioate ester derivatives of androstane with a cyclic ester group in position 17.alpha
AssigneeGlaxo Group Limited
InventorsKeith Biggadike, Paul Jones, Jeremy John Payne
Life of this patent
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Abstract
There are provided compound of formula (I) wherein R1 represents C1-6 alkyl or C1-6 haloalkyl; R2 represents C3-8 cycloalkyl or C3-8 cycloalkenyl either of which may optionally be substituted by one or more groups selected from oxo, methyl, methylene and halogen; R3 represents hydrogen, methyl (which may be in either the α or β configuration) or methylene; R4 and R5 are the same or different and each represents hydrogen or halogen; and (AA) represents a single or a double bond; and solvates thereof, processes for preparing them and their use in therapy. 1
Claims26
A compound of formula (I)
- 10
- wherein
- R1 represents C1-6. alkyl or C1-6 haloalkyl;
- R2 represents C3-8 cycloalkyl or C3-8 cycloalkenyl either of which may optionally be substituted by one or more groups selected from oxo, methyl, methylene and halogen;
- R3 represents hydrogen, methyl (which may be in either the α or β configuration) or methylene;
- R4 and R5 are the same or different and each represents hydrogen or halogen;
- and
- represents a single or a double bond;
- and solvates thereof.
6 more elements
Dependencies are inferred from the claim text.