Heterocycles and uses thereof

A compound of the general formula (I)):

• 32
• wherein:
• RB is a substituted or unsubstituted aryl or heteroaryl moiety;
• at least one of RU and RL is a phosphorus-containing moiety, J, which is covalently linked to the quinazoline ring through a carbon-phosphorous bond,
• and the other of RU and RL is independently chosen from H;
• halogen;
• —CN;
• —NO2;
• —J;
• —SO2R;
• —SO2NRR′;
• or —ZRJ, wherein each occurrence of Z is independently —O—, —S— or —NR—and each occurrence of RJ is independently —R, —COR, —COOR or —CONRR′;
• each occurrence of R, R′, R″, etc.(i.e., without further alphanumeric designation) is independently hydrogen, or an aliphatic, heteroaliphatic, aryl or heteroaryl moiety;
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• K is O or S;
• each occurrence of Y is independently —O—, —S—, —NR—, or a chemical bond;
• each occurrence of R5 is independently an aliphatic, heteroaliphatic, aryl or heteroaryl moiety, or (except when attached directly to P, e.g., in YR5 moieties in which Y is a chemical bond) R5 may be H (Thus, in —P(O)(R5)2, for example, R5 may not be H.);
• each occurrence of R6 is independently R5, —PK(YR5)(YR5), —SO2(YR5) or —C(O)(YR5) wherein two of the R5 and/or R6 moieties may be chemically linked to one another to form a ring;
• each occurrence of G is independently —O—, —S—, —NR— or MX;
• each occurrence of MX is independently a 1-6 carbon aliphatic moiety;
• and
• in each of the foregoing groups each aliphatic or heteroaliphatic moiety may be branched or unbranched, cyclic or acyclic, substituted or unsubstituted, and may contain one or more electronically unsaturated bonds;
• and each aryl and heteroaryl moiety may be substituted or unsubstituted.