Antisense modulation of interferon gamma receptor 2 expression
OwnerC. Frank Bennett, Andrew T. Wattinventors
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Abstract
Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
Claims10
A compound 8 to 50 nucleobases in length targeted to a region consisting of nucleobases 741 through 974 of a nucleic acid molecule encoding human Interferon gamma receptor 2 (SEQ ID NO:
- 3), wherein said compound is an antisense oligonucleotide which comprises at least one modified internucleoside linkage and wherein said compound specifically hybridizes with said region and inhibits the expression of human Interferon gamma receptor 2.
Dependencies are inferred from the claim text.