Growth hormone and growth hormone releasing hormone compositions
OwnerMohamad A. Morsey, Michael G. Sheppardinventors
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Abstract
The present invention relates to methods and compositions of growth hormone and/or growth hormone releasing hormone that promote of the release and the elevation of growth hormone when administered to animals. The present invention further relates to methods and compositions of growth hormone and/or growth hormone releasing hormone for treatment of diseases or disorders resulting from growth hormone related deficiencies. The invention also provides methods for producing novel growth hormone releasing hormone variants and their uses thereof.
Claims39
A method for the treating growth hormone related disorders characterized by growth hormone deficiencies in an animal, comprising supplying the animal with a polynucleotide sequence that encodes growth hormone releasing hormone or modified growth hormone releasing hormone.
A method for improving the growth and performance of an animal, comprising supplying the animal with a polynucleotide sequence that encodes growth hormone releasing hormone or modified growth hormone releasing hormone.
A method for the treating growth hormone related disorders characterized by growth hormone deficiencies in an animal, comprising supplying the animal with a polynucleotide sequence that encodes growth hormone or modified growth hormone.
A method for improving the growth and performance of an animal, comprising supplying the animal with a polynucleotide sequence that encodes growth hormone or modified growth hormone.
A growth hormone releasing hormone (GHRH) variant comprising the addition of one amino acid to the amino terminus of a 29 amino acid amino terminal fragment of GHRH, in a pharmaceutical formulation suitable for delivery to a human or livestock.
A growth hormone releasing hormone variant comprising the addition of two or three amino acids to the amino terminus, of a 29 amino acid amino terminal fragment of GHRH wherein the second amino acid is not proline or alanine, and in a pharmaceutical formulation suitable for delivery to a human or livestock.
A method for the treating growth hormone related disorders characterized by growth hormone deficiencies in an animal, comprising supplying the animal with an effective amount of a polypeptide of claim 35.
Dependencies are inferred from the claim text.