Method for detection of neoplastic cells
AssigneeJohns Hopkins School of Medicine
InventorsDavid Sidransky, Stephen B. Baylin
Life of this patent
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Abstract
Methylation of p16 DNA and a resultant decrease in p16 gene expression is associated with transcriptional block and is associated with a variety of neoplasms. A method for detecting a neoplasm in a subject by doming methylation of 5′CpG islands in p16 DNA, or detecting p16 mRNA or polypeptide levels in a sample is also provided.
Claims11
A method of treating a cell proliferative disorder associated with 5′ALT polynucleotide(s), comprising contacting the cell having or suspected of having the disorder with a reagent which modulates 5′ALT.
A method of treating a cell proliferative disorder associated with altered p16 expression comprising administering to a subject with the disorder, a therapeutically effective amount of reagent which modulates p16 expression.
Dependencies are inferred from the claim text.