Antisense oligonucleotide modulation of human serine/threonine protein phosphatase gene expression
OwnerRichard E. Honkanen, Nicholas M. Deaninventors
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Abstract
Oligonucleotides are provided which are targeted to nucleic acids encoding human serine/threonine protein phosphatases and which are capable of inhibiting protein phosphatase expression. Methods of inhibiting the expression of human protein serine/threonine phosphatases using oligonucleotides of the invention are also provided. The present invention further comprises methods of preventing or inhibiting hyperproliferation of cells and methods of treating abnormal conditions, including cancer, using oligonucleotides of the invention.
Claims9
An antisense oligonucleotide between 20 and 50 nucleobases in length, comprising at least an 8 nucleobase region of nucleobases 61-1922 of a nucleic acid molecule encoding human protein phosphatase 5 (PP5)(SEQ ID NO:
- 43), wherein said oligonucleotide inhibits expression of human PP5 by at least 50%.
Dependencies are inferred from the claim text.