Prodrugs of DP IV-inhibitors
AssigneeProsidion Limited
InventorsHans-Ulrich Demuth, Dagmar Schlenzig, Torsten Hoffmann, Susanne Manhart
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Abstract
The present invention relates to prodrug compounds of inhibitors of dipeptidyl peptidase IV (DP IV), which prodrug compounds have the general formula A-B-C, wherein A is an amino acid, B is a chemical bond between A and C or is an amino acid, and C is a stable inhibitor of DP IV. Such prodrug compounds are used in the treatment of impaired glucose tolerance, glucosuria, hyperlipidaemia, metabolic acidoses, diabetes mellitus, diabetic neuropathy and nephropathy and of sequelae of diabetes mellitus in mammals.
Claims12
Prodrug compounds of inhibitors of dipeptidyl peptidase IV (DP IV), which prodrug compounds have the general formula A-B-C, wherein
- A is an amino acid,
- B is a chemical bond between A and C or is an amino acid, and
- C is a stable inhibitor of DP IV.
Prodrug compounds according to one of the preceding claims, characterised in that C is an aminoacylpyrrolidide, aminoacylthiazolidide or N-dipeptidyl, O-acyl hydroxylamine.
Prodrug compounds according to one of the preceding claims, characterised in that the inhibitors are present in salt form.
Prodrug compounds according to one of the preceding claims, characterised in that A-B is a dipeptide of formula Ile-Pro or Gly-Pro.
Pharmaceutical composition, especially for oral administration, characterised in that it comprises at least one prodrug compound according to one of the preceding claims optionally in combination with customary carriers or excipients.
Use of prodrug compounds or pharmaceutical compositions according to one of the preceding claims in the preparation of a medicament for the temporally controlled in vivo inhibition of DP IV.
Dependencies are inferred from the claim text.