Novel chemokine binding peptides capable of modulating the biological activity of chemokines
AssigneeBiokine Therapeutics Ltd.
InventorsAmnon Peled, Orly Eizenberg, Dalit Vaizel-Ohayon
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Abstract
Novel peptidic or peptidomimetic agents or small molecules for modulating the biological effect of a chemokine. According to the present invention, the therapeutic agents preferably are endowed with the capacity to bind to certain chemokines in order to modulate the biological interaction between the target ligand, chemokine, and the respective target receptor, chemokine receptor. These peptides may be described as agonist ligands or antagonists. Next, preferably certain peptides share consensus sequences are described which characterize the families or categories of these modulator peptides.
Claims76
A peptidic chemokine modulator for modulating a biological effect of a chemokine, comprising a molecule composed of the amino acids H. S, A, L, I, K, R, T and P, and featuring at least 2 Histidines spread along said molecule, wherein said molecule features an overall positive charge (family 1).
A peptidic chemokine modulator for modulating a biological effect of a chemokine, comprising a molecule composed of the amino acids H, P, T, L, R, W, F, and featuring at least two neighboring histidines, wherein said molecule features an overall positive charge (family 2).
A peptidic chemokine modulator for modulating a biological effect of a chemokine, wherein said molecule comprises a peptide having an amino acid sequence from Table 1.
Dependencies are inferred from the claim text.