Molecules binding to Glu-Pro motifs, therapeutic compositions containing them and their applications
AssigneesInstitut Gustave Roussy - IGR, a corporation of France, Universite Paris-Sud, a corporation of France
InventorFrederic Triebel
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Abstract
A molecule binding to a target including an EP motif having the following sequence: (X-(EP)n-Y-(EP)m-Z)p wherein X, Y and Z may be identical or different and include a sequence of 0 to 10 amino acids, identical or different, n and m are integers between 0 to 20, preferably between 3 to 10, with at least one of n or m being different from 0, and p is an integer between 1 and 10.
Claims30
1) A molecule binding to a target comprising an EP motif having the following sequence:
- (X-(EP)n-Y-(EP)m-Z)p
- wherein X, Y and Z may be identical or different and comprise a sequence of 0 to 10 amino acids, identical or different, n and m are integers between 0 to 20, preferably between 3 to 10, with at least one of n or m being different from 0, and p is an integer between 1 and 10.
26) Antibodies directed to a specific epitope of a polypeptide selected from the group consisting of polypeptides or peptides identified by SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, and SEQ ID NO:9.
28) A monoclonal antibody or a monoclonal antibody derivative that specifically binds a peptide selected from the group consisting of polypeptides or peptides identified by SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6 and SEQ ID NO:9, the monoclonal antibody derivative being selected from the group consisting of a monoclonal antibody conjugated to a cytotoxic agent or a radioisotope, and Fab, Fab′ or F(ab′)2 fragments of said monoclonal antibody conjugated to a cytotoxic agent or radioisotope.
Dependencies are inferred from the claim text.