Trefoil domain-containing polypeptides and uses thereof
OwnerNicholas P. Barker, Daniel K. Podolskyinventors
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Abstract
The invention features compositions and methods for treating and preventing epithelial lesions and disorders by administering trefoil domain-containing polypeptides and trefoil peptide fragments. The trefoil domain-containing polypeptides and trefoil peptide fragments can be administered alone or in combination with other therapeutic agents.
Claims42
A method for treating or preventing an epithelial lesion in a mammal comprising administering a trefoil domain-containing polypeptide (TDCP) or a trefoil peptide fragment.
A pharmaceutical composition comprising a trefoil domain-containing polypeptide (TDCP) or trefoil peptide fragment and a pharmaceutically acceptable carrier.
A method for producing hITF21-72 or hITF21-73 comprising providing a microorganism capable of expressing recombinant hITF21-72 or recombinant hITF21-73 and culturing said microorganism at about pH 5.0.
A method for producing hITF15-72 or hITF15-73 comprising providing a microorganism capable of expressing recombinant hITF15-72 or recombinant hITF15-73 and culturing said microorganism at about pH 6.0-pH 6.5.
Dependencies are inferred from the claim text.