Methods and compositions for regulating adiopocytes
OwnerBarbara Zehentner, Ulrike Leser-Reiff +1inventors
InventorsBarbara Zehentner, Ulrike Leser-Reiff, Helmut Burtscher
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Abstract
The present application relates to a method for modulating the formation and/or maintenance of adipocyte tissue by ectopically contacting adipocyte cells, especially adipocyte stem/progenitor cells, in vitro or in vivo, with a hedgehog therapeutic or ptc therapeutic in an amount effective to alter the growth state the treated cells, e.g., relative to the absence of administeration of the hedgehog therapeutic or ptc therapeutic.
Claims26
A method for regulating formation and/or maintenance of adipocyte tissue comprising contacting pre-adipocyte or adipocyte cells with a hedgehog polypeptide or a ptc therapeutic.
A therapeutic preparation of a small molecule antagonist of patched, which patched antagonist is provided in a pharmaceutically acceptable carrier and in an amount sufficient to regulate growth and/or maintenance of adipocyte cells.
A method for regulating the growth state of a adipocyte stem/progenitor cell comprising contacting the cell with a hedgehog polypeptide or a ptc therapeutic.
A method for treatment or prevention of disorders of, or surgical or cosmetic repair of, such adipocyte tissues, comprising administering to the patient a hedgehog polypeptide or a ptc therapeutic.
Dependencies are inferred from the claim text.