Non-aqueous surfactant-containing formulations for extended release of somatotropin

A composition of matter, comprising:

• a) somatotropin,
• b) a first bioavailability enhancing constituent (BEC), and,
• c) optionally, a second BEC;
• wherein the first BEC comprises one or a mixture of two or more of the following:
• polyoxyethylene 4 stearate, polyoxyethylene 8 stearate, polyoxyethylene(20) sorbitan monooleate (Tween® 80), hydroxypropyl beta cyclodextrin, and wherein the second BEC is selected from one or more of the following:
• non-reducing carbohydrate, amino acid, amino acid derivative, amino acid polymer, hydroxamate or hydroxamate derivative, or an oxo-acid salt.

A method for eliciting a desired physiological response in a susceptible animal comprising:

• parenterally administering to the animal a biocompatible composition of matter comprising:
• a) a somatotropin, active in the animal;
• b) a first bioavailability enhancing constituent (BEC);
• and,
• c) optionally, a second BEC;
• wherein the first BEC is selected from a non-ionic surfactant or a cyclodextrin, and wherein the second BEC is selected from one or a mixture of two or more of the following:
• a non-reducing carbohydrate, an amino acid, an amino acid derivative, an amino acid polymer, an hydroxamate or hydroxamate derivative, or an oxo-acid salt.

A method for sustaining elevated milk production response in a lactating mammal comprising:

• parenterally administering to the mammal a biocompatible composition of matter comprising:
• a) a somatotropin, active in the mammal;
• b) a first bioavailability enhancing constituent (BEC);
• and,
• c) optionally, a second BEC;
• wherein the first BEC is selected from a non-ionic surfactant or a cyclodextrin, and wherein the second BEC is selected from one or a mixture of two or more of the following:
• a non-reducing carbohydrate, an amino acid, an amino acid derivative, an amino acid polymer, an hydroxamate or hydroxamate derivative, or an oxo-acid salt.