Antimicrobial, synthetic, fibrous, and tubular medical divices
OwnerShalaby W. Shalabyinventor
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Abstract
The present invention is directed toward antimicrobial absorbable and non-absorbable fibrous and tubular medical devices comprising synthetic polymers and one or more antimicrobial agent molecularly dispersed within the surface to allow the continuous release of said agent or agents under simulated physiologic conditions for at least one week.
Claims16
An antimicrobial, synthetic, polymeric, medical device comprising a device surface defining a surface-air interface and having at least one active agent molecularly dispersed, preferentially within the surface, and having a concentration gradient wherein a maximum concentration of the at least one active agent is present at or adjacent to the surface-air interface and wherein the concentration of the at least one active agent within the device decreases with the distance from the surface-air interface, such that in the biologic environment the at least one active agent is released in accordance with a controlled release profile, initially displaying essentially first-order kinetics and subsequently displaying essentially zero-order kinetics.
Dependencies are inferred from the claim text.