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AssigneesUniversity of Pittsburgh—Of the Commonwealth System of Higher Education, The Regents of the University of California
InventorsAdam J. Katz, Ramon Llull, J. William Futrell, Marc H. Hedrick, Prosper Benhaim, Hermann Peter Lorenz, Min Zhu
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The present invention provides adipose-derived stem cells and lattices. In one aspect, the present invention provides a lipo-derived stem cell substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The cells can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the cells can be expanded and cultured to produce hormones and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect the present invention provides a lipo-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.
A mammalian lipo-derived stem cell substantially free of mature adipocytes.
A defined cell population consisting essentially of mesodermal stem cells (MHC), connective tissue stem cell (CTSC), or mixtures thereof, wherein the population is clonal.
A lipo-derived lattice comprising adipose tissue extracellular matrix matter substantially devoid of cells.
An implant comprising the population of any of 8-13.
A kit for isolating stem cells from adipose tissues comprising a means for isolating adipose tissue from a patient and a means for separating stem cells from the remainder of the adipose tissue.
Dependencies are inferred from the claim text.