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US 2004/0171132 A1Published application
Recombinant infectious laryngotracheitis virus and uses thereof
AssigneeSyntro Corporation
InventorsMartha A. Wild, Mark D. Cochran
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AssigneeSyntro Corporation
InventorsMartha A. Wild, Mark D. Cochran
Estimating the term…
The present invention provides a recombinant, attenuated infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the glycoprotein gG gene. This attenuated virus is useful as a vaccine against infectious laryngotracheitis virus. The present invention also provides a recombinant, attenuated infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the US2 gene, UL47-like gene, ORF4 gene or glycoprotein g60 gene. The present invention also provides a method for distinguishing chickens or other poultry vaccinated with a recombinant infectious laryngotracheitis virus which produces no glycoprotein gG from those infected with a naturally occuring infectious laryngotracheitis virus.
A recombinant infectious laryngotracheitis virus comprising an infectious laryngotracheitis viral genome which contains a deletion in the unique short region of the infectious laryngotracheitis viral genome, wherein the deletion is in the glycoprotein G (gG) gene.
A recombinant infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the unique short region of the viral genome, wherein the deletion is in the glycoprotein gG gene, so that upon replication the recombinant infectious laryngotracheitis virus produces no glycoprotein gG.
A recombinant infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the unique short region of the viral genome, wherein the deletion is in the glycoprotein gI gene, so that upon replication, the recombinant infectious virus produces no glycoprotein gI.
The recombinant infectious laryngotracheitis virus comprising the infectious laryngotracheitis viral genome which contains a deletion in the unique short region of the viral genome, wherein the deletion is in a gene selected from a group consisting of the US2 gene, the UL47-like gene, and the glycoprotein g60 gene.
A homology vector for producing a recombinant infectious laryngotracheitis virus by deleting DNA which encodes a screenable marker, which has been inserted into the infectious laryngotracheitis virus genomic DNA, which comprises a double stranded DNA molecule consisting essentially of a double-stranded DNA to be deleted, which is flanked on each side by a double stranded DNA homologous to the infectious laryngotracheitis virus glycoprotein gG gene, glycoprotein gI gene, US2 gene, or UL-47 like gene.
Dependencies are inferred from the claim text.