Anti-RANK ligand monoclonal antibodies useful in treatment of RANK ligand mediated disorders
AssigneeSmithKline Beecham Corporation
InventorsMark A. Tornetta, Raymond W. Sweet, Alemseged Truneh, Trevor A. Wattam
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Abstract
Chimeric, humanized and other RANK-L MAbs, derived from high affinity neutralizing MAbs, pharmaceutical compositions containing same, methods of treatment and diagnostics are provided.
Claims13
Monoclonal antibody of that has the identifying characteristics of monoclonal antibody 19H22.
An antibody comprising an immunoglobulin complementarity determining region of monoclonal antibody 19H22.
An antibody which comprises the polypeptides having the amino acid sequences of SEQ ID NOs:5, 6, 7, 8, 9 and 10.
An antibody which comprises the polypeptides having the amino acid sequences of SEQ ID NOs:
- 2 and 4.
Isolated polynucleotides which encode an antibody comprising the polypeptides having the amino acid sequences of SEQ ID NOs:5, 6, 7, 8, 9 and 10.
Isolated polynucleotides which encode an antibody comprising the polypeptides having the amino acid sequences of SEQ ID NOs:
- 2 and 4.
Expression systems comprising polynucleotides which encode an antibody comprising the polypeptides having the amino acid sequences of of SEQ ID NOs:5, 6, 7, 8, 9 and 10 capable of producing such antibody when said expression vectors are present in a compatible host cell, and recombinant host cells comprising such expression vectors.
A process for producing an antibody which comprises the polypeptides having the amino acid seqeunces of SEQ ID NOs:5, 6, 7, 8, 9 and 10 comprising the step of culturing said host cells under conditions sufficient for the production of said antibody and recovering the antibody from the culture medium.
Expression systems comprising polynucleotides which encode an antibody comprising the polypeptides having the amino acid sequences of of SEQ ID NOs:
- 2 and 4 capable of producing such antibody when said expression vectors are present in a compatible host cell, and recombinant host cells comprising such expression vectors.
A process for producing an antibody which comprises the polypeptides having the amino acid seqeunces of SEQ ID NOs:2 and 4 comprising the step of culturing said host cells under conditions sufficient for the production of said antibody and recovering the antibody from the culture medium.
Dependencies are inferred from the claim text.