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US 2004/0171113 A1Published application
Antigens of group b streptococcus and corresponding dna fragments
OwnerDenis Martin, Josee Hamel +3inventors
InventorsDenis Martin, Josee Hamel, Bernard R Brodeur, Stephane Rioux, Martine Boyer
Life of this patent
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Abstract
The present invention relates to antigens, more particularly antigens of Group B Streptococcus (GBS) (S. agalactiae) which may be useful to prevent, diagnose and/or treat streptococcal infections.
Claims35
An isolated polynucleotide comprising a polynucleotide chosen from:
- (a) a polynucleotide encoding a polypeptide having at least 80% identity to a second polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2 or fragments or analogs thereof;
- (b) a polynucleotide encoding a polypeptide having at least 95% identity to a second polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2 or fragments or analogs thereof;
- (c) a polynucleotide encoding a polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2 or fragments or analogs thereof;
- (d) a polynucleotide encoding a polypeptide capable of raising antibodies having binding specificity for a polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2 or fragments or analogs thereof;
- (e) a polynucleotide encoding an epitope bearing portion of a polypeptide comprising a sequence chosen from SEQ ID NO:
- 2 or fragments or analogs thereof;
- (f) a polynucleotide comprising a sequence chosen from SEQ ID NO:
- 1 or fragments or analogs thereof;
- (g) a polynucleotide that is complementary to a polynucleotide in (a), (b), (c), (d), (e) or (f).
14 more elements
An isolated polynucleotide comprising a polynucleotide chosen from:
- (a) a polynucleotide encoding a polypeptide having at least 80% identity to a second polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2;
- (b) a polynucleotide encoding a polypeptide having at least 95% identity to a second polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2;
- (c) a polynucleotide encoding a polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2;
- (d) a polynucleotide encoding a polypeptide capable of raising antibodies having binding specificity for a polypeptide comprising a sequence chosen from:
- SEQ ID NO:
- 2;
- (e) a polynucleotide encoding an epitope bearing portion of a polypeptide comprising a sequence chosen from SEQ ID NO:
- 2;
- (f) a polynucleotide comprising a sequence chosen from SEQ ID NO:
- 1;
- (g) a polynucleotide that is complementary to a polynucleotide in (a), (b), (c), (d), (e) or (f).
14 more elements
An isolated polynucleotide that hybridizes under stringent conditions to either
- (a) a DNA sequence encoding a polypeptide or
- (b) the complement of a DNA sequence encoding a polypeptide;
- wherein said polypeptide comprises SEQ ID NO:2 or fragments or analogs thereof.
An isolated polypeptide comprising a polypeptide chosen from:
- (a) a polypeptide having at least 80% identity to a second polypeptide having an amino acid sequence comprising:
- SEQ ID NO:
- 2, or fragments or analogs thereof;
- (b) a polypeptide having at least 95% identity to a second polypeptide having an amino acid sequence comprising:
- SEQ ID NO:
- 2, or fragments or analogs thereof;
- (c) a polypeptide comprising a sequence chosen from SEQ ID NO:
- 2, or fragments or analogs thereof;
- (d) a polypeptide capable of raising antibodies having binding specificity for a polypeptide comprising SEQ ID NO:
- 2, or fragments or analogs thereof;
- (e) an epitope bearing portion of a polypeptide comprising SEQ ID NO:
- 2, or fragments or analogs thereof;
- (f) the polypeptide of (a), (b), (c), (d), or (e) wherein the N-terminal Met residue is deleted;
- (g) the polypeptide of (a), (b), (c), (d), (e), or (f) wherein the secretory amino acid sequence is deleted.
11 more elements
An isolated polypeptide comprising a polypeptide chosen from:
- (a) a polypeptide having at least 80% identity to a second polypeptide having an amino acid sequence comprising:
- SEQ ID NO:
- 2;
- (b) a polypeptide having at least 95% identity to a second polypeptide having an amino acid sequence comprising:
- SEQ ID NO:
- 2;
- (c) a polypeptide comprising a sequence chosen from SEQ ID NO:
- 2;
- (d) a polypeptide capable of raising antibodies having binding specificity for a polypeptide comprising SEQ ID NO:
- 2;
- (e) an epitope bearing portion of a polypeptide comprising SEQ ID NO:
- 2;
- (f) the polypeptide of (a), (b), (c), (d), or (e) wherein the N-terminal Met residue is deleted;
- (g) the polypeptide of (a), (b), (c), (d), (e), or (f) wherein the secretory amino acid sequence is deleted.
11 more elements
A chimeric polypeptide comprising two or more polypeptides having a sequence chosen from SEQ ID NO:
- 2, or fragments or analogs thereof;
- provided that the polypeptides are linked as to formed a chimeric polypeptide.
A chimeric polypeptide comprising two or more polypeptides having a sequence chosen from SEQ ID NO:
- 2;
- provided that the polypeptides are linked as to formed a chimeric polypeptide.
Dependencies are inferred from the claim text.