Detection of inflammation
AssigneeScheBo Biotech AG
InventorsBert Schlatterer, Regine Baeker, Ursula Scheefers-Borchel, Hans Scheefers
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Abstract
The invention relates to a method for the detection of inflammations, in particular of inflammatory processes in the tissue of mammary glands in humans or animals, in particular in cattle and a test-kit for carrying out said method. The method is particularly suitable for the specific detection of inflammations in mammary glands, for example during testing of milk, whereby the enzyme implicated in inflammatory processes prostaglandin D synthase (PGDS) is qualitatively or quantitatively determined.
Claims20
A method for detection of inflammation,
- characterized
- in that the enzyme prostaglandin D synthase (PGDS) or parts of it is or are determined qualitatively and/or quantitatively, and in that the inflammation to be detected is chosen from mammary gland inflammation or rheumatic arthritis.
The method as claimed in one of the preceding claims,
- characterized
- in that the determination is made using at least one antibody against prostaglandin D synthase.
The method as claimed in one of the preceding claims,
- characterized
- in that the determination is made by means of a immunoassay, in particular a quantitative sandwich ELISA or a Western Blot.
The method as claimed in one of the preceding claims,
- characterized
- in that the detection is made with the aid of mass spectroscopy, in particular MALDI-TOF or by means of gel electrophoresis, in particular two-dimensional gel electrophoresis.
Use of an aptamer or of an antibody against prostaglandin D synthase (PGDS) in order to produce a means for detection of inflammation.
Use of an aptamer or of an antibody against prostaglandin D synthase (PGDS) in order to produce a means for detection of mammary gland inflammation.
An aptamer,
- characterized
- in that the aptamer specifically binds the enzyme prostaglandin D synthase (PGDS).
Dependencies are inferred from the claim text.