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US 2004/0171093 A1Published application
Methods for detecting deficient cellular membrane tightly bound magnesium for disease diagnoses
OwnerIbert C. Wellsinventor
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OwnerIbert C. Wellsinventor
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This invention relates to methods for detecting the deficiency of magnesium tightly bound to plasma membranes of somatic cells, referred to as the magnesium binding defect. The invention also relates to methods for assessing certain abnormal physiological states, such as, salt-sensitive essential hypertension, type 2 overt or prediabetes mellitus, and preeclampsia/eclampsia syndrome that are associated with the magnesium binding defect. The invention further relates to methods for generating magnesium deficient cell membranes and for identifying substances which promote binding of magnesium ions to the plasma membranes of somatic cells. Additionally, the invention relates to a binding pair members having affinity for the peptides and promoters of the invention.
A method of assessing a predisposition to a physiological disorder associated with magnesium binding defect in an individual, compising:
A method for monitoring progress in treatment of a physiological disorder associated with magnesium binding defect in an individual, comprising:
A monoclonal antibody that specifically binds to a peptide or its peptide mimetic comprising:
A method for generating a deficit of plasma membrane tightly bound magnesium ion in mammalian somatic cells, comprising:
A method for identifying substances which promote binding of tightly bound magnesium ion to a plasma membrane of mammalian somatic cells, comprising:
The method of claim 25, wherein said mammalian somatic cells having a deficit of plasma membrane tightly bound magnesium are generated by the method of claim 26.
Dependencies are inferred from the claim text.