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Assignee3M Innovative Properties Company
InventorsJason R. Fink, Keith B. Gorden, Kevin S. Gorski, Shalley K. Gupta, Xiaohong Qiu, John P. Vasilakos
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Methods of identifying a compound that selectively modulates at least one TLR-mediated cellular activity are disclosed. Generally, the methods include identifying a compound as a compound that selectively modulates at least one TLR-mediated cellular activity if the compound modulates one TLR-mediated cellular activity to a different extent than it modulates a second TLR-mediated cellular activity. Compounds so identified and pharmaceutical compositions including such compounds are also disclosed. Methods of selectively modulating immune cells and methods of treating certain conditions are also provided. Such methods include administering to cells or a subject a compound that selectively modulates a TLR-mediated cellular activity.
A method of identifying a compound that selectively modulates at least one TLR-mediated cellular activity, the method comprising:
A method of identifying a target compound having a TLR modulation profile that conforms to a target TLR modulation profile, the method comprising:
A method of selectively modulating cells of the immune system, the method comprising:
A method of treating a condition treatable by selective modulation of a plurality of TLR-mediated cellular activities in a subject, the method comprising:
Dependencies are inferred from the claim text.