Detectable micro to nano sized structures, methods of manufacture and use
OwnerMatthew J. Dejneka, Joydeep Lahariinventors
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Abstract
Homogeneously mixed rare-earth doped particles and methods of using such particles include nano to microsized particles having a concentration of at least about 0.0005 mole percent of a Rare-Earth Oxide (Re2O3). The particles can be used for detecting the presence of an analyte in a sample and for detecting interactions of biomolecules.
Claims20
A biological-library indicia glass or ceramic composition comprising a micro to nanosized particle homogeneously doped with at least two different rare earth (RE) elements.
The composition of 3, wherein the rare earth element is in a concentration below the onset of concentration quenching of less than about 0.25 mole percent of a Rare-Earth Oxide (Re2O3) wherein the Rare-Earth component is selected from the group consisting of Ce, Pr, Nd, Sm, Dy, Ho, Er, Tm, or U and combinations thereof.
The composition of claim of 3, wherein the rare earth element is in a concentration of less than about 20 mole percent of a Rare-Earth Oxide (Re2O3) with Re selected from Eu, Tb, or Yb.
A method of detecting multiple functional groups comprising the steps of:
- providing spectrally coded glass particles, each of the glass particles having a functional group associated therewith;
- illuminating the glass particles with a light source;
- obtaining a spectral signature of the glass particles, wherein the spectral signature of each individual particle includes the fluorescent emission from at least two different rare earth elements;
- and
- utilizing the spectral signature to decode the glass particles, wherein the rare earth elements are randomized to provide a unique code for each glass particle based on the fluorescent emission from at least one rare earth element.
A biological-library indicia composition comprising:
- a plurality of coded rare-earth homogeneously doped nano to micro sized glass carriers, each having N>1 specified rare earth dopants and one of M>1 detectable intensity levels for each color, such that each carrier can be identified by one of up to M to the N power of different code combinations;
- and
- a different known biological compound carried on each different-combination carrier.
Dependencies are inferred from the claim text.