Gene sequence variations with utility in determining the treatment of disease, in genes relating to drug processing
AssigneeVariagenics, Inc., a Delaware corporation
InventorVincent P. Stanton JR.
Life of this patent
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Abstract
Methods for identifying and utilizing variances in genes relating to efficacy and safety of medical therapy and other aspects of medical therapy are described, including methods for selecting an effective treatment.
Claims16
A nucleic acid probe comprising a nucleic acid sequence 7 to 500 nucleotide bases in length that specifically binds under selective binding conditions to a nucleic acid sequence comprising at least one variance in a gene selected from the group consisting of Human glutamate dehydrogenase (EC 1.4.1.3., GDH), Cytochrome P-450 (CYP3 A4), Human acyl coenzyme A:cholesterol acyltransferase, Homo sapiens P-type ATPase FIC1, Human neutral amino acid transporter B, Human E16, H.sapiens canalicular multidrug resistance protein, Human organic anion transporting polypeptide (OATP), Carboxylesterase I, H.sapiens REC1L or a sequence complementary thereto or an RNA equivalent.
An isolated, purified or enriched nucleic acid sequence of 15 to 500 nucleotides in length, comprising at least one variance, wherein said sequence has the base sequence of a portion of an allele of a gene selected from the group consisting of Human glutamate dehvdroienase (EC 1.4.1.3., GDH), Cytochrome P-450 (CYP3A4), Human acyl coenzyme A:cholesterol acyltransferase, Homo sapiens P-type ATPase FIC1, Human neutral amino acid transporter B, Human E16, H.sapiens canalicular multidrug resistance protein, Human organic anion transporting polypeptide (OATP), Carboxylesterase I, H.sapiens REC1L or a sequence complementary thereto or an RNA equivalent.
Dependencies are inferred from the claim text.