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OwnerMartin Nicklin, Gordon Duff +5inventors
InventorsMartin Nicklin, Gordon Duff, Kenneth Kornman, Maryam Rafie Kolpin, Chung-Ming Hsieh, Raju Govindaraju, Nazneen Aziz
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The invention provides methods and compositions relating to identification and use of genetic information from the IL-1 gene cluster—including the structure and organization of novel IL-1-like genes found within the IL-1 locus as well as polymorphisms and associated haplotypes within these genes. The invention thereby expands the repertoire of useful genetic information available from the IL-1 locus—which contains the previously-identified IL-1α, IL-1β and IL-1RN genes, for predicting IL-1 associated phenotypes (e.g. increased or decreased risks of inflammatory disease) and for treating IL-1 haplotype associated inflammatory phenotypes.
A method for determining whether a subject has or is predisposed to developing a disease or condition that is associated with an IL-1 inflammatory haplotype comprising detecting an IL-1 allele as shown in any of FIGS. 1, 2A, 2B, 7A or 7B.
A method for determining whether a subject has or is predisposed to developing a disease or condition that is associated with an IL-1 inflammatory haplotype phenotype comprising detecting a characteristic pattern of an IL-1 haplotype as shown in any of FIGS. 3A, 3B, 4A, 4B, 5A, 5B, 6A, or 6B.
An IL-1 polynucleotide sequence for detecting an IL-1 polymorphism comprising a novel nucleic acid of at least 12 contiguous nucleotides of an SNP sequence shown in any of FIGS. 8, 9, 10A, 10B or 11, or its complement.
A kit for IL-1 genotyping comprising at least two polynucleotides of at least 12 contiguous nucleotides selected from the group consisting of:
A method for selecting an appropriate therapeutic for an individual that has or is predisposed to developing a disease or disorder that is associated with an IL-1 polymorphism comprising the steps of:
A method for determining whether a particular therapeutic is effective in treating an individual with an inflammatory disease phenotype comprising
Dependencies are inferred from the claim text.