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OwnerBrenda F. Baker, Anne B. Eldrup +5inventors
InventorsBrenda F. Baker, Anne B. Eldrup, Muthiah Manoharan, Balkrishen Bhat, Richard H. Griffey, Eric E. Swayze, Stanley T. Crooke
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Compositions comprising first and second oligomers are provided wherein at least a portion of the first oligomer is capable of hybridizing with at least a portion of the second oligomer, at least a portion of the first oligomer is complementary to and capable of hybridizing to a selected target nucleic acid, and at least one of the first or second oligomers includes a modification comprising a sugar surrogate. Oligomer/protein compositions are also provided comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein comprising at least a portion of an RNA-induced silencing complex (RISC), wherein at least one nucleoside of the oligomer has a sugar surrogate modification.
A composition comprising a first oligomer and a second oligomer, wherein:
18 The composition of claim 11 wherein the sugar surrogate is a cyclopentyl nucleoside.
19 The composition of claim 18 wherein the cyclopentyl nucleoside is of the formula:
A composition comprising an oligomer complementary to and capable of hybridizing to a selected target nucleic acid and at least one protein, said protein comprising at least a portion of a RNA-induced silencing complex (RISC), wherein:
An oligomer having at least a first region and a second region, wherein:
Dependencies are inferred from the claim text.