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AssigneeAgilent Technologies, Inc.
InventorsEric M. Leproust, Douglas A. Amorese, Mel N. Kronick
Estimating the term…
Methods and devices for detecting deposition unit misalignment, e.g., printhead misalignment, of an in situ polymeric, e.g., a nucleic acid, array synthesis device are provided. In accordance with the subject methods, at least one test probe feature is synthesized on a substrate using an in situ polymeric array, e.g., nucleic acid array or protein array, synthesis device. The at least one test probe feature is then contacted with at least two different distinguishably labeled targets, e.g., target nucleic acids. The binding of the targets to the at least one test probe feature is then evaluated to detect any misalignment, e.g., deposition unit or pulse jet misalignments, of the synthesis device. Also provided are substrates having at least one test probe feature and at least one polymeric array, as well as methods of using the substrates in array assays. Also included are kits for use in practicing the subject methods.
A method of detecting deposition unit misalignment of an in situ polymeric array synthesis device, said method comprising:
A method of detecting printhead misalignment of an in situ nucleic acid array synthesis device, said method comprising:
A substrate comprising at least one nucleic acid array and at least one test probe feature, wherein said at least one test probe feature is made up of only two different nucleotides chosen from the group of A, C, T and G or is made up of four different nucleotides.
A kit for detecting printhead misalignment of an in situ nucleic acid array synthesis device, said kit comprising:
Dependencies are inferred from the claim text.