Molecules capable of binding to telomere and the like and method with the use of the same

A method for forming a mimetic base pair of a base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain by the use of a compound of the following general formula (I) to thereby stabilize the base pair therein not capable of forming a normal base pair among the base pairs of the single-stranded oligonucleotide chain:

• A—L—B (I)
• wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair that fails to form a normal base pair;
• B represents a chemical structural moiety capable of forming a pair with the other base of that base pair failing to form a normal base pair;
• and L represents a linker structure that binds the chemical structures A and B.

A stabilizer for base pair forming in a single-stranded oligonucleotide chain, which comprises a compound of the following general formula (I) and which is to form a mimetic base pair of a mismatch base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain:

• A—L—B (I)
• wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair that fails to form a normal base pair;
• B represents a chemical structural moiety capable of forming a pair with the other base of that base pair failing to form a normal base pair;
• and L represents a linker structure that binds the chemical structures A and B.

An inhibitor for inhibiting the activity of an enzyme that synthesizes a complementary chain to an oligonucleotide chain, which comprises a compound of the following general formula (I) to form a mimetic base pair of a base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain:

• A—L—B (I)
• wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair that fails to form a normal base pair;
• B represents a chemical structural moiety capable of forming a pair with the other base of that base pair failing to form a normal base pair;
• and L represents a linker structure that binds the chemical structures A and B.

A method for inhibiting the activity of an enzyme that synthesizes a complementary chain to an oligonucleotide chain, which comprises forming a mimetic base pair of a base pair that fails to form any normal base pair among the base pairs of a single-stranded oligonucleotide chain by the use of a compound of the following general formula (I):

• A—L—B (I)
• wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair that fails to form a normal base pair;
• B represents a chemical structural moiety capable of forming a pair with the other base of that base pair failing to form a normal base pair;
• and L represents a linker structure that binds the chemical structures A and B.

A pharmaceutical composition comprising a compound which may form a mimetic base pair of a base pair that fails to form a normal base pair among the base pairs of a single-stranded oligonucleotide and which is represented by the following general formula (I):

• A—L—B (I)
• wherein A represents a chemical structural moiety capable of forming a pair with one base of a base pair that fails to form a normal base pair;
• B represents a chemical structural moiety capable of forming a pair with the other base of that base pair failing to form a normal base pair;
• and L represents a linker structure that binds the chemical structures A and B, and a pharmaceutically-acceptable carrier.