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OwnerAndrew Darrow, Jenson Qi +1inventors
InventorsAndrew Darrow, Jenson Qi, Patricia Andrade-Gordon
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Here we describe the molecular identification of a cDNA encoding a novel serine protease we have termed protease EOS. The deduced amino acid sequence, and it alignment with other well-characterized serine proteases indicates that it is a member of the S1 serine protease family. We have found that the protease EOS mRNA is expressed in platelets and leukocytes and more specifically eosinophils. Although this protease is abundantly expressed in ovary, retina and stomach, where it may perform important functions, its expression in platelets and certain cells of the immune system suggests that it may play roles in thrombosis and in the immune process. Enzymatically active protease EOS is amenable to further biochemical analyses for the identification of physiological substrates and specific modulators
An isolated and purified nucleic acid molecule that encodes protease EOS, and functional derivatives thereof.
An expression vector for expression of protease EOS protein in a recombinant host, wherein said vector contains a nucleic acid sequence encoding protease EOS protein, and functional derivatives thereof.
A protein in substantially pure form that functions as protease EOS protein.
A monospecific antibody immunologically reactive with protease EOS protein.
A method of identifying compounds that modulate protease EOS protein activity, comprising:
A kit comprising the nucleic acid sequence selected from the group consisting of SEQ.ID.NO.:1 and SEQ.ID.NO.:8, nucleotide sequence encoding SEQ.ID.NO.:7, and fragments thereof.
A kit comprising the serine protease EOS protein selected from the group consisting of SEQ.ID.NO.:7 and SEQ.ID.NO.:9, and fragments or derivatives thereof.
Dependencies are inferred from the claim text.