Assays for detection of bacillus anthracis
AssigneeBiosite, Inc.
InventorsBruce A. Lee, Becky Mar Flores, Gunars E. Valkirs
Life of this patent
Estimating the term…
Abstract
This invention provides novel methods, reagents, and kits that are useful for detecting B. anthracis. The methods are based on the discovery of binding agents, including recombinant polyclonal antibodies, which bind to the surface array protein of B. anthracis.
Claims32
A method of detecting the presence or absence of Bacillus anthracis in a test sample, the method comprising:
- contacting a test sample with a capture reagent that can bind to a Bacillus anthracis surface array protein, wherein the capture reagent forms a complex with the surface array protein if the surface array protein is present in the test sample;
- and
- detecting whether surface array protein is bound to the capture reagent, wherein the presence of surface array protein is indicative of the presence of Bacillus anthracis in the test sample.
A kit for detecting the presence or absence of Bacillus anthracis in a sample, the kit comprising:
- a solid support upon which is immobilized a capture reagent that can bind to a surface array protein of Bacillus anthracis;
- and
- a detection reagent which binds to the surface array protein.
A recombinant polyclonal antibody preparation that specifically binds to an antigenic determinant of a surface array protein of Bacillus anthracis.
Dependencies are inferred from the claim text.