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AssigneesCnrs, I.N.R.A.
InventorsRima Zoorob, Charles Auffray, Anne-Marie Chausse
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The invention relates to nucleic acid molecules which make it possible to detect those genes of the MHC involved in the phenomena of resistance or susceptibility to the development of virus-induced tumours. The primers developed from said molecules can be used in a method of genotyping farmed birds, and particularly chickens, characterised in that it comprises: amplification of a sample of nucleic acid originating from the animal to be studied using one or more pairs of primers capable of hybridising specifically with the nucleic acid of a polymorphic region of the Rfp-Y or B systems of the MHC of said birds, and detection of the PCR products obtained.
Nucleic acid molecules, isolated from their natural environment, of genes coding for proteins involved in controlling resistance or susceptibility to the development of tumours in chickens, such as those of Marek's disease, and of regions related to the said genes, characterised in that they have nucleic acid sequences of genes of the B or Rfp-Y system corresponding to the major histocompatibility complex of farmed birds, with the exception of the sequences of class II B-L genes, gene 17.5, gene 12.3 and of the class I B-FIV gene, or are capable of pairing with one of the strands of a gene capable of coding for a protein as defined above under conditions of low stringency.
Method of genotyping farmed birds and particularly chickens, characterised in that it comprises:
Dependencies are inferred from the claim text.