Polymeric network system for medical devices and methods of use
AssigneeBioInteractions Ltd.
InventorsAjay K. Luthra, Shivpal S. Sandhu
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Abstract
Methods of making a coating on a medical device are disclosed, including associating a composition with at least a portion of the device to form a layer. In some embodiments, a composition may include a copolymer prepared from a room temperature melt of a plurality of monomer units that comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit.
Claims154
A method of making a coating on a medical device for delivery of a therapeutic agent, the method comprising associating a composition with at least a portion of the device to form a first layer, wherein the composition comprises the therapeutic agent associated with a copolymer that has a molecular weight of at least about 2500, wherein the copolymer comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit.
A coating for a medical device for delivery of a therapeutic agent, the coating comprising a layer having a composition associated with at least a portion of the device, wherein the composition comprises the therapeutic agent associated with a copolymer that has a molecular weight of at least about 2500, wherein the copolymer comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit.
A method of making a coating on a medical device, the method comprising associating a composition with at least a portion of the device to form a layer, wherein the composition comprises a copolymer that has a molecular weight of at least about 2500, wherein the copolymer is prepared from a room temperature melt of a plurality of monomer units that comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit.
The method of claim 300 further comprising a second layer that contacts at least a portion of the first layer, wherein the second layer and the first layer have a different composition.
An expandable medical device associated with a material for delivery of a therapeutic agent, the material comprising a composition associated with at least a portion of an expandable portion of the expandable medical device, wherein the composition comprises the therapeutic agent associated with a copolymer that has a molecular weight of at least about 2500, wherein the copolymer comprises a first monomer unit and a second monomer unit, wherein the second monomer unit has a glass transition temperature that is at least about 30 degrees Centigrade higher than the glass transition temperature of the first monomer unit, with a glass transition temperature of a monomer unit being defined as a glass transition temperature of a homopolymer of that monomer unit with at least a portion of an expandable portion of a medical device.
Dependencies are inferred from the claim text.