Compositions and methods for non-insulin glucose uptake
OwnerDusan Miljkovic, Jovan Hranisavljevic +1inventors
InventorsDusan Miljkovic, Jovan Hranisavljevic, Zbigniew Pietrzkowski
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Abstract
Compositions and methods are provided to increase glucose uptake in a cell. Particularly contemplated compositions include a compound that is isolated from a plant that has AICAR-like activity. In another aspect of the invention, contemplated compositions comprise a non-insulin compound that has AICAR-like activity and activates AMPK in a cell.
Claims27
A composition comprising a compound isolated from a plant, wherein the compound has AICAR (5′-aminoimidazole 4-carboxamide 1-ribonucleotide)-like activity and increases glucose uptake into a cell.
A composition comprising:
- a compound having AICAR (5′-aminoimidazole 4-carboxamide 1-ribonucleotide)-like activity and wherein the compound increases glucose uptake into a cell;
- wherein the compound is identical with a molecule isolated from Hordeum vulgare;
- and
- wherein the molecule isolated from Hordeum vulgare reduces blood glucose in an organism when the molecule is administered to the organism at a concentration effective to reduce the concentration of glucose.
A non-insulin compound that has AICAR (5′-aminoimidazole 4-carboxamide 1-ribonucleotide)-like activity and activates AMPK in a cell.
A method of treating a cell comprising:
- identifying the cell as having a condition that activates an AMPK (adenosine 5′-monophosphate-activated protein kinase);
- and
- presenting the cell with a compound having AICAR (5′-aminoimidazole 4-carboxamide 1-ribonucleotide)-like activity at a concentration effective to modulate at least one of an import, export, and synthesis of a molecule.
Dependencies are inferred from the claim text.