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US 2004/0170697 A1Published application
Amniotic apoptosis modulating substances
OwnerVladimir Bakhutashviliinventor
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OwnerVladimir Bakhutashviliinventor
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This invention is directed to methods of obtaining compounds from human amniotic tissue and/or by synthesizing these compounds by chemical and genetic engineering methods known in the art that modulate apoptosis in animals, including humans, their preparation, their applications in human conditions for the treatment of all disease conditions and other conditions in which apoptosis occurs and in laboratory tests for diagnostic studies and other potential uses. The invention describes methods of obtaining compositions that modulate apoptosis and compositions obtained thereby. These compositions are herein referred to as Amnion Apoptosis Modulators (AAM). AAM includes materials comprised of biologically active factors found in amniotic tissue and amniotic fluid associated therewith. AAM could be manufactured from the amniotic tissue of mammalian origin—human, pig etc. All AAMs, derived from amnions or chemically or genetically prepared are physiologically acceptable for administration in amount sufficient to modulate apoptosis. The invention encompasses methods of use of the AAMs.
Amniotic apoptosis modulating substances.
A composition with apoptosis modulating activity obtainable from human amniotic tissue prepared according to a method comprising the steps of:
A composition with apoptosis modulating activity obtainable from human amniotic tissue prepared according to a method comprising the steps of:
A composition with apoptosis modulating activity derived from human amniotic tissue, amnion tissue products or tissue.
A composition with apoptosis modulating activity produced chemically or by using genetic engineering or by synthesis.
A method for producing a composition with derived from human amniotic tissue, amnion tissue products or tissue activity obtainable from human amniotic tissue comprising the steps of:
A method for producing a composition with apoptosis modulating activity obtainable from human amniotic tissue comprising the steps of:
A method for producing a composition derived from human amniotic tissue, amnion tissue products or tissue activity obtainable from amniotic tissue and/or prepared from chemical formulation, genetic engineering or synthesis.
A method for improving the skin condition of a subject comprising contacting an effective amount of a composition with anti-apoptotic, anti-wrinkle, anti-aging, or anti-drying activity obtainable from human amniotic tissue with said skin surface on the subject.
A method for normalizing the biochemical parameters of liver function and immunologic indices in an acute viral hepatitis B subject, speeding recovery from symptoms of the disease, and preventing recurrence of the disease with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of normalizing cell counts of CD3+, CD4+, CD8+, and T-cells carrying HLA-DR antigens and improving neurological symptoms in a herpes zoster ganglioneuritis subject with an anti-apoptotic composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of normalizing levels of CD3+ and CD4+ T-cell phenotypes in a diabetic peripheral polyneuropathy subject with an apoptosis modulating obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of promoting earlier and prolonged clinical laboratory remission in a child with Idiopathic Nephropathy Syndrome (INS) and correcting the reduction in CD3+ and CDB+ T lymphocytes in the same subject with an apoptosis modulating composition obtainable from human amniotic tissue combined with prednisolone by administering an effective amount of the composition to the subject.
A method of improving clinical symptoms and laboratory indices, stimulating leukocyte interferon-genesis and normalizing humoral and cellular immunity in a juvenile rheumatoid arthritis, rheumatoid arthritis or psoriatic arthritis subject with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of reducing the average daily dose of oral steroid required for relief;
A method of improving immunological indices and decreasing the frequency of infections in a pediatric patient with respiratory infection with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of reducing allergic reactions and drug toxicity in an epileptic subject who uses anticonvulsants with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of immunomodulation, normalizing of levels of the tumor serum marker, CA15.3, and increasing tumor-infiltrating CD5′ T-cells and CD11 macrophages in an early breast cancer subject with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of improving clinical symptoms, eradicating rash, relieving pain, increasing activity of immunoregulatory lymphocytes and percentages of CD3+ and CD8 in a psoriasis subject with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating atherososclerotic and other forms of vascular obstructions that cause ischemia of the myocardium and other tissues in a human subject with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of limiting myocardial cell death due to viral and immunogenic myocardiopathies with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of limiting the rejection reaction that follows organ transplantation with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating HIV infection with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating brain ischemia and trauma with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating the pathologic consequences of ischemia-reperfusion with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating alcohol and morphine intoxication with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating wound healing with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A method of treating viral diseases with an apoptosis modulating composition obtainable from human amniotic tissue by administering an effective amount of the composition to the subject.
A composition with apoptosis modulating activity obtainable from human amniotic tissue having characteristic peaks as set forth in FIG. 2.
A composition with apoptosis modulating activity obtainable from human amniotic tissue having at least one characteristic peak as set forth in FIG. 2.
A composition with apoptosis modulating activity obtainable from human amniotic tissue having characteristic peaks as set forth in FIG. 3.
A composition with apoptosis modulating activity obtainable from human amniotic tissue having at least one characteristic peak as set forth in FIG. 3.
A composition capable of inhibiting or killing cancer cells, wherein said composition is obtainable from human amniotic tissue with apoptosis modulating activity.
A composition which is antagonistic to H1-histamine receptor, wherein said composition is obtainable from human amniotic tissue with apoptosis modulating activity.
A composition which is inhibitory to A2-phospholipase activity, wherein said composition is obtainable from human amniotic tissue with apoptosis modulating activity.
A composition for protecting cardiomyocytes, wherein said composition is obtainable from human amniotic tissue with apoptosis modulating activity.
A composition for protecting against the effects of Tumor Necrosis Factor (TNF), wherein said composition is obtainable from human amniotic tissue with apoptosis modulating activity.
Dependencies are inferred from the claim text.