Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them
AssigneeHenceforth Hibernia, Inc.
InventorMiroslav Colic
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Abstract
The invention discloses therapeutic and prophylactic compositions based on synthetic solid catalysts such as zeolites, clays, silicates, silicas and double hydroxides. These solids can be used to treat numerous disease conditions such as diabetes, arthritis and other autoimmune diseases, cancer, skin diseases, microbial infections etc. The invention also describes methods to produce such products and use them independently or in combination with other pharmaceutically and biologically active ingredients. Such catalysts are designed so to imitate biological catalytic systems (enzymes, antigen presenting cells, delayed active component release, cell organeles, etc.) and are, therefore, biomimetic.
Claims14
A pharmaceutical composition for therapeutic or prophylactic use comprising a silica containing solid having an average particle size of about 6 microns or less.
A method to modify gene expression, cell proliferation, death, growth rate or differentiation by administering to a mammal a silica containing solid as an antioxidant or oxidant.
A method to enhance immunogeneity of protein antigens, other biological macromolecules, whole cells or cell fragments by administering to a mammal in need thereof a silica containing solid as a vaccine adjuvant in combination with protein antigens, whole cells or cell fragments.
A method for providing sustained delivery of a pharmaceutically active agent by using a silica containing solid as a reservoir for the pharmaceutically active agent.
Dependencies are inferred from the claim text.