Calcium phosphate bodies and a process for making calcium phosphate bodies
AssigneeThe Curators of the University of Missouri
InventorsDelbert E. Day, Xue Han, Kenan Patrick Fears
Life of this patent
Estimating the term…
Abstract
Among the various aspects of the present invention is a process for making calcium phosphate bodies comprising amorphous calcium phosphate, hydroxyapatite or calcium triphosphate, the bodies themselves and the use of such bodies in any of a variety of applications.
Claims57
A calcium phosphate body wherein the body is an calcium phosphate agglomerate, the agglomerate being a product of an agglomeration as a plurality of water-soluble glass bodies is transformed into a plurality of calcium phosphate bodies.
A process for making a calcium phosphate body comprising contacting a water-soluble glass body in the form of a sphere with a diameter of less than about 1 μm, fiber, flake or ellipsoid and a phosphate solution wherein the water-soluble glass body contains about 1 to about 40 wt. % CaO, about 5 to about 65 wt. % alkali metal oxide component and about 20 to about 94 wt. % of a glass former.
A process for making an agglomerate of calcium phosphate bodies comprising contacting a plurality of water-soluble glass bodies with a phosphate solution and allowing the calcium phosphate bodies to fuse together as the water-soluble glass bodies are transformed to calcium phosphate bodies.
A method for delivering a fluid comprising (a) heat treating a calcium phosphate body at a temperature between about 30° C. and about 1500° C., (b) filling the calcium phosphate body with the fluid and (c) administering the calcium phosphate body filled with the fluid to a subject.
A method for separating a chemical species from a fluid containing the species by affinity chromatography comprising (a) contacting the fluid with a macroscopically smooth calcium phosphate body to adsorb the chemical species onto the calcium phosphate body, (b) separating the fluid from the calcium phosphate body and (c) desorbing the species from the calcium phosphate body.
A method for use of a calcium phosphate body as a bone substitute comprising administering the calcium phosphate body to a subject.
A method for use of a calcium phosphate body as a diagnostic imaging agent comprising (a) filling the calcium phosphate body with a gas, (b) heat treating the calcium phosphate body and (c) administering the gas filled calcium phosphate body to a subject.
A regular or irregular particle of hydroxyapatite prepared from molded or crushed water-soluble glass, other than glass containing 20-35 wt% CaO, 20-35 wt. % Na2O, 0-10 wt. % P2O5 and 30-50 wt. % B2O3, transformed in a phosphate solution at a temperature of less than about 100° C.
Dependencies are inferred from the claim text.