Compositions with improved stability and methods of formulation thereof
AssigneeIntegrity Pharmaceutical Corporation
InventorsWilliam R. Hurd, Michael J. Dempsey, William C. Williams
Life of this patent
Estimating the term…
Abstract
Ingredients in pharmaceutical compositions are provided with a coating material for improving stability thereof. The coating material prevents reactive contact between otherwise incompatible ingredients in the composition. Without contact, incompatible ingredients will not degrade thereby prolonging the stability and shelf life of the composition.
Claims61
A pharmaceutical composition comprising at least two ingredients of which a first ingredient is reactive with a second ingredient, the composition in a formulation wherein at least one of the first ingredient and the second ingredient further contains a coating thereby reducing the reactivity between the ingredients.
A pharmaceutical composition comprising hyoscyamine and phenyl salicylate in a formulation wherein at least one of the hyoscyamine and the phenyl salicylate contain a barrier to physical contact with the other thereby reducing the reactivity between the hyoscyamine and the phenyl salicylate in the formulation.
A pharmaceutical composition comprising granules of hyoscyamine evenly dispersed with phenyl salicylate in a solid formulation wherein the hyoscyamine contains a polymeric coating thereby reducing reactivity between the hyoscyamine and the phenyl salicylate.
A method for improving the stability of a pharmaceutical composition, the method comprising:
- providing at least two ingredients for inclusion in the composition, a first ingredient of which is reactive with a second ingredient;
- coating at least one of the first and second ingredients with a coating material independently of the other ingredient;
- and
- formulating the ingredients whereby the coating reduces reactivity between the ingredients thereby improving the stability of the composition.
A method for improving the stability of a pharmaceutical composition, the method comprising:
- providing hyoscyamine or a pharmaceutically acceptable salt thereof and phenyl salicylate for inclusion in the composition;
- coating at least one of the hyoscyamine and the phenyl salicylate with a coating material;
- and
- dispersing the hyoscyamine evenly with the phenyl salicylate in the composition wherein the coating material reduces reactivity between the hyoscyamine and the phenyl salicylate for improving stability of the composition.
A formulation method for preventing a reaction between a first active ingredient and a second active ingredient in a formulation, the method comprising
- combining a solution of the first active ingredient with a carrier to form granular first active ingredient;
- coating the granular first active ingredient with a coating material;
- drying the coated first active ingredient;
- and
- formulating the coated first active ingredient with the second active ingredient whereby the first active ingredient is rendered non-reactive with the second ingredient in the formulation.
A pharmaceutical formulation formed by the process of:
- providing hyoscyamine or a pharmaceutically acceptable salt thereof and phenyl salicylate for inclusion in the formulation;
- coating at least one of the hyoscyamine and the phenyl salicylate with a coating material;
- and
- evenly dispersing the hyoscyamine and phenyl salicylate in the formulation whereby the coating material reduces reactivity between the hyoscyamine and the phenyl salicylate.
Dependencies are inferred from the claim text.