Suspension vehicle for coated drug particles

A dry formulation, comprising:

• at least two doses of coated drug particles having an average particle size of about 50 μm to about 600 μm, each coated drug particle comprising a core comprising a drug, and a hydrophobic polymer film coating at least a portion of the core;
• xanthan gum;
• and
• a combination of microcrystalline cellulose and sodium carboxymethylcellulose;
• wherein the weight ratio of the xanthan gum to the combination of microcrystalline cellulose and sodium carboxymethylcellulose is about 1:2 to about 1:0.2, and wherein a suspension with a viscosity of at least about 1500 cps is formed after combination of the dry formulation with about 2 ml to about 60 ml of an aqueous liquid per dose of the coated drug particles.

A method of producing a multi-dose suspension, comprising the steps of:

• a) providing a dry formulation comprising:
• at least two doses of coated drug particles having an average particle size of about 50 μm to about 600 μm, each coated drug particle comprising a core comprising a drug, and
• a hydrophobic polymer film coating at least a portion of the core, xanthan gum, and a combination of microcrystalline cellulose and sodium carboxymethylcellulose,
• wherein the weight ratio of the xanthan gum to the combination of microcrystalline cellulose and sodium carboxymethylcellulose is about 1:2 to about 1:0.2;
• and
• b) combining the dry formulation with an aqueous solution and agitating the same until a suspension is formed, having a viscosity of at least about 1500 cps.