Bioactive stents and methods for use thereof
AssigneeMediVas, LLC
InventorsKenneth W. Carpenter, Huashi Zhang, Brendan J. McCarthy, Istvan Szinai, William G. Turnell, Sindhu M. Gopalan
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Abstract
The present invention is based on the discovery that stents can be coated with biodegradable, bioactive polymers that promote endogenous healing processes at a site of stent implantation. The polymers biodegrade over time, releasing agents which establish or re-establish the natural healing process in an artery. Preferably, the stent is implanted at the time an artery is damaged, such at the time of angioplasty to protect the damaged artery against deleterious blood-borne factors that initiate proliferation of smooth muscle cells.
Claims67
A bioactive implantable stent comprising a stent structure with a surface coating of a biodegradable, bioactive polymer, wherein the polymer comprises at least one bioactive agent covalently bound to the polymer, and wherein the at least one bioactive agent produces a therapeutic effect in situ.
A bioactive vascular stent comprising a stent structure with a surface coating of a biodegradable, bioactive polymer, wherein at least one ligand for promoting re-endothelialization of endothelial cells is covalently bonded to the polymer.
A tubular sheath comprising a biodegradable, bioactive polymer, wherein the polymer comprises at least one bioactive agent covalently bound to the polymer.
A bioactive implantable stent comprising a stent structure with a surface coating of a biodegradable, bioactive polymer, wherein the polymer produces a therapeutic effect in situ as a result of biodegradation of the polymer.
A biodegradable stent, wherein the stent comprises a cross-linked biodegradable polymer.
A method of using a polymer as a medical device, a pharmaceutical, or as a carrier for covalent immobilization of a bioactive agent, wherein the polymer comprises at least one bioactive agent covalently bound to the polymer
A bioactive implantable stent comprising:
- a porous stent structure;
- and
- a multilayered tubular coating encapsulating the stent structure, the multilayered coating comprising:
- an outer drug-eluting biodegradable polymer layer, which sequesters an unbound drug;
- and
- an inner layer of a biodegradable, bioactive polymer, wherein the polymer comprises at least one bioactive agent covalently bound to the polymer, and wherein the at least one bioactive agent produces a therapeutic effect in situ;
- and
- an biodegradable barrier layer lying between and in contact with the outer layer and the inner layer and which barrier layer is impermeable to the drug.
Dependencies are inferred from the claim text.